![]() Secondary outcomes were an independent blinded clinical ASD diagnosis at age 3 years and measures of child development. Primary outcome was the combined blinded measure of ASD behavior severity (the Autism Observation Scale for Infants and the Autism Diagnostic Observation Schedule, second edition) across the 4 assessment points. Main Outcomes and Measures Infants were assessed at baseline (approximate age, 12 months), treatment end point (approximate age, 18 months), age 2 years, and age 3 years. Usual care comprised services delivered by community clinicians. The preemptive intervention group received a 10-session social communication intervention, iBASIS–Video Interaction to Promote Positive Parenting (iBASIS-VIPP). Interventions Infants were randomized on a 1:1 ratio to receive either a preemptive intervention plus usual care or usual care only over a 5-month period. Final follow-up data were collected on April 15, 2020. Recruitment occurred from June 9, 2016, to March 30, 2018. Community sampling was used to recruit 104 infants aged 9 to 14 months showing early behaviors associated with later ASD, as measured by the Social Attention and Communication Surveillance–Revised. ![]() Objective To determine the efficacy of a preemptive intervention for ASD beginning during the prodromal period.ĭesign, Setting, and Participants This 2-site, single rater–blinded randomized clinical trial of a preemptive intervention vs usual care was conducted at 2 Australian research centers (Perth, Melbourne). No trial of an intervention administered to infants before diagnosis has shown an effect on diagnostic outcomes to date. Importance Intervention for individuals with autism spectrum disorder (ASD) typically commences after diagnosis. Shared Decision Making and Communication. ![]()
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